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The Sidney Kimmel Foundation for Cancer Research Announces 2010 Cancer Research Grant Recipients

 

For Immediate Release

Contact: Risa B. Hoag, risa@kimmel.org

 

PHILADELPHIA, April 7, 2010 -- The Sidney Kimmel Foundation for Cancer Research has selected fifteen scientists from across the United States to receive two year grants under the Foundation's on-going Kimmel Scholar program. A total of 187 talented cancer researchers have been provided with grant money since the Foundation's inception with each receiving a $200,000 award to further a specific cancer research project.

 

The Kimmel Scholar Awards were created in 1997 to advance the careers of gifted, young scientists involved in cancer research. Scientists are selected who show the greatest promise and innovation, but whose careers have not evolved sufficiently to provide them the critical mass of prior research that typically justifies receiving major grants from the National Cancer Institute and other funding sources.

 

Sidney Kimmel, the organization's founder and chairman of the board of Jones Apparel Group and president of Sidney Kimmel Entertainment, meets each year with the Foundation's medical advisory board and observes as the esteemed group of leading cancer doctors narrows down the applicants. Since 1997 Kimmel has contributed more than $550 million to cancer centers and cancer research and another $100 million to the arts and Jewish continuity.

 

Many of the exceptional young scientists who have their careers 'jump started' by the Sidney Kimmel Foundation for Cancer Research go on to receive millions of dollars in funding from the NCI and NIH and make significant contributions to the field of cancer research. Many report that they might never have achieved such success without first receiving the Kimmel grant.

 

This year’s recipients are:              

           

*          Maximillian Diehn, M.D., Ph.D.

            Stanford University School of Medicine

            “Exploring Metabolic Properties of Tumor Initiating Cells”

 

Matthew Gamble, Ph.D

Albert Einstein College of Medicine

“Exploring the interplay between macro domains and poly (ADP-ribose) polymerases in tumor progression and suppression”

 

 

Zev Gartner, Ph.D.

University of California, San Francisco

“Unraveling the relationship between tissue structure and cancer progression”

 

*          Rani George, M.D., Ph.D.

Dana-Farber Cancer Institute

“Functional analysis of ALK mutations in neuroblastoma”

 

A.      McGarry Houghton, M.D.

University of Pittsburgh

“IRS1-Mediated Regulation of PI3K and MEK/ERK Activity in Lung Cancer”

 

Antoine Karnoub, Ph.D.

Beth Israel Deaconess Medical Center

“Role of Stem Cells in the Metastatic Spread of Breast Carcinomas”

 

*          Alec Kimmelman, M.D., Ph.D.

Dana-Farber Cancer Institute

“Defining Biomarkers of Autophagy Addiction in Human Cancers”

 

Ivan Maillard, M.D., Ph.D.

University of Michigan 

“Role of the Ash1L histone methyltransferase in normal and malignant hematopoiesis”

 

Michael Major, Ph.D.

University of North Carolina at Chapel Hill

“New Functional Components of the KEAP1 Tumor Suppressor Protein Complex”

 

Ashby Morrison, Ph.D.

Stanford University

“A Novel Mechanism for Tumor Suppression by the Retinoblastoma Protein”

 

*          Donald Parsons, M.D., Ph.D.

            Baylor College of Medicine

            “Defining molecular subtypes of hepatoblastoma”

 

Flavia Pichiorri, Ph.D.

Ohio State University

“microRNAs in multiple myeloma diagnosis, prognosis and therapy”

 

Xiaobing Shi, Ph.D.

University of Texas, M.D. Anderson Cancer Center

“The roles of PHD fingers in dynamic histone lysine methylation and human cancer”

 

Alexander Stegh, Ph.D.

Northwestern University

“Development and Characterization of Bcl2L12-driven GBM Mouse Models”

 

*          Nicola Valeri, M.D.

            Ohio State University

“MicroRNA-mediated modulation of genomic stability and apoptosis in sporadic and inflammatory bowel disease associated colon cancer”

 

* Translational Scholars

 

 

 

The Foundation is particularly interested in helping physicians who are engaged in research which can rapidly be translated into benefits for patients with cancer.  This year five of the fifteen awards have been designated for such "Translational Research.”

 

The Sidney Kimmel Foundation for Cancer Research has also funded four cancer centers at San Diego, Memorial Sloan-Kettering Cancer Center, Thomas Jefferson University and Johns Hopkins University. The gift to Johns Hopkins, $150 million, is the largest gift ever received by that institution. In the area of arts and culture, The Kimmel Foundation has supported the Kimmel Center for the Performing Arts in Philadelphia as well as the United States Holocaust Memorial Museum in Washington D.C., among others. For more information visit www.kimmel.org.

 

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The Sidney Kimmel Foundation For Cancer Research Announces 2009 Cancer Research Grant Recipients

FOR IMMEDIATE RELEASE
Contact: Risa B. Hoag, risa@kimmel.org

PHILADELPHIA, May 5, 2009 -- The Sidney Kimmel Foundation for Cancer Research has selected twelve scientists from across the United States to receive two year grants under the Foundation's on-going Kimmel Scholar program. A total of 172 talented cancer researchers have been provided with grant money since the Foundation's inception with each receiving a $200,000 award to further a specific cancer research project.

The Kimmel Scholar Awards were created in 1997 to advance the careers of gifted, young scientists involved in cancer research. Scientists are selected who show the greatest promise and innovation, but whose careers have not evolved sufficiently to provide them the critical mass of prior research that typically justifies receiving major grants from the National Cancer Institute and other funding sources.

Sidney Kimmel, the organization's founder and chairman of the board of Jones Apparel Group and president of Sidney Kimmel Entertainment, meets each year with the Foundation's medical advisory board and observes as the esteemed group of leading cancer doctors narrows down the applicants. This year there were nearly 150 grant applications for review.

Kimmel has contributed more than $500 million to cancer centers and cancer research since 1997 and another $100 million to the arts and Jewish continuity.

Many of the exceptional young scientists who have their careers 'jump started' by the Sidney Kimmel Foundation for Cancer Research go on to receive millions of dollars in funding from the NCI and NIH and make significant contributions to the field of cancer research. Many report that they might never have achieved such success without first receiving the Kimmel grant.

This year’s recipients are:

*Valerie Brown, M.D, Ph.D. Children's Hospital of Philadelphia “Preclinical evaluation of targeting the mTOR signaling network in acute lymphoblastic leukemia”

Paul Chang, Ph.D. Massachusetts Institute of Technology “New PARP isoforms for cancer therapies”

Lara Collier, Ph.D. University of Wisconsin, Madison “Genetic approaches to studying glioma formation and therapy resistance”

Muller Fabbri, M.D. Ohio State University Research Foundation “Role of p53 regulation of microRNAs and ultraconserved regions in human cancer”

Danica Galonic Fujimori, Ph.D. University of California, San Francisco “Histone-modifying enzymes in cancer: elucidating roles of histone demethylases”|

*Erich Huang, M.D., Ph.D. Duke University Medical Center “Oncogenic network interrogation for elucidating colon cancer tumorigenesis and identifying novel combination therapies”

Terry Lechler, Ph.D. Duke University Medical Center “Mechanism of asymmetric cell divisions and their role in tumor suppression”

*Alexander Minella, M.D. Northwestern University Feinberg School of Medicine “Deregulated cell cycle controls in the pathogenesis of hematopoietic cancers”

*Sohail Tavazoie, M.D., Ph.D. Rockefeller University “Dissecting the mechanisms that regulate the expression of human metastasis suppressor microRNAs”

Andrea Ventura, M.D., Ph.D. Memorial Sloan Kettering Cancer Center “Functional analysis of the miR-17~92 family of oncogenic miRNA clusters”

Bin Wang, Ph.D. M.D. Anderson Cancer Center “Functional analysis of new regulatory components in BRCA1 signaling and tumor suppression”

Zefeng Wang, Ph.D. University of North Carolina at Chapel Hill “Engineering artificial splicing factors with designed specificities as new cancer treatments”

* Translational Scholars

The Foundation is particularly interested in helping physicians who are engaged in research which can rapidly be translated into benefits for patients with cancer. This year four of the twelve awards have been designated for such "Translational Research.”

The Sidney Kimmel Foundation for Cancer Research has also funded four cancer centers at San Diego, Memorial Sloan-Kettering Cancer Center, Thomas Jefferson University and Johns Hopkins University. The gift to Johns Hopkins, $150 million, is the largest gift ever received by that institution. In the area of arts and culture, The Kimmel Foundation has supported the Kimmel Center for the Performing Arts in Philadelphia as well as the United States Holocaust Memorial Museum in Washington D.C., among others. For more information visit www.kimmel.org.

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The Sidney Kimmel Foundation Announces 2008 Cancer Research Grant Recipients

FOR IMMEDIATE RELEASE
Contact: Risa B. Hoag, risa@kimmel.org

PHILADELPHIA, April 2008 -- The Sidney Kimmel Foundation for Cancer Research has selected sixteen scientists from across the United States to receive two year grants under the Foundation's on-going Kimmel Scholar program. A total of 160 talented cancer researchers have been provided with grant money since the Foundation's inception with each receiving a $200,000 award to further a specific cancer research project.

The Kimmel Scholar Awards were created in 1997 to advance the careers of gifted, young scientists involved in cancer research. Scientists are selected who show the greatest promise and innovation, but whose careers have not evolved sufficiently to provide them the critical mass of prior research that typically justifies receiving major grants from the National Cancer Institute and other funding sources.

Sidney Kimmel, the organization's founder and chairman of the board of Jones Apparel Group and president of Sidney Kimmel Entertainment, meets each year with the Foundation's medical advisory board and observes as the esteemed group of leading cancer doctors narrows down the applicants. This year there were nearly 200 grant applications for review.

Kimmel has contributed more than $350 million to cancer centers and cancer research since 1997 and another $100 million to the arts and Jewish continuity.

Many of the exceptional young scientists who have their careers 'jump started' by the Sidney Kimmel Foundation for Cancer Research go on to receive millions of dollars in funding from the NCI and NIH and make significant contributions to the field of cancer research. Many report that they might never have achieved such success without first receiving the Kimmel grant.

This year’s recipients are:

Nabeel Bardeesy, Ph.D. Massachusetts General Hospital “Function of the WTX tumor suppressor”

* Barbara Buttin, M.D. Northwestern University “The role of synuclein-gamma (SNCG) in the carcinogenesis of uterine papillary serous carcinoma”

Richard Gardner, Ph.D. University of Washington “Understanding the roles of protein deubiquitination in chromatin regulation and other vital nuclear processes”

* Ramiro Garzon, M.D. Ohio State University “Epigenetic modulation of DNA methyltransferases by miR-29b: a paradigm for developing novel hypomethylating strategies in AML”

* Roger Greenberg, M.D., Ph.D. University of Pennsylvania School of Medicine “Control of homologous recombination at DNA double strand break sites by manipulating lysine-63-linked ubiquitin metabolism”

Patrick Hu, M.D., Ph.D. University of Michigan “Novel regulators of FoxO tumor supressors”

Tae Hoon Kim, Ph.D. Yale University “Genome-wide analysis of chromatin barriers”

Karen Liby, Ph.D. Darthmouth Medical School “New drugs and drug combinations for the prevention and treatment of cancer”

* Ingo Mellinghoff, M.D. Memorial Sloan-Kettering Cancer Center "Overcoming PTEN-associated resistance of EGFRkinase inhibitors in Glioblastoma"

Raul Mostoslavsky, M.D., Ph.D. Massachusetts General Hospital “The role of the SIRT6 chromatin factor in DNA repair and in metabolic homeostasis”

Cathie Pfleger, Ph.D. Mount Sinai School of Medicine “Identification and characterization of mutations in non-tumor cells that promote metastasis”

Jeroen Roose, Ph.D. University of California, San Francisco “Increased RasGRP1 function leads to aberrantly sensitized Ras activation and development of T cell lymphomas in humans”

Lanlan Shen, M.D., Ph.D. University of Texas, M.D. Anderson Cancer Center “Epigenetic reprogramming in cancer”

Hengbin Wang, Ph.D. University of Alabama, Birmingham “Role of Ubp-M and H2A deubiquitination in breast cancer development”

* Jen Jen Yeh, M.D. University of North Carolina at Chapel Hill "Identification and validation of novel targets for the treatment of pancreatic cancer using a prognostic gene signature"

Hang Yin, Ph.D. University of Colorado, Boulder “Novel peptide probes to study the activation mechanism of the Epstein-Barr Virus latent membrane protein 1”

* Translational Scholars

The Foundation is particularly interested in helping physicians who are engaged in research which can rapidly be translated into benefits for patients with cancer. Five of the sixteen awards have been designated for such "Translational Research.”

The Sidney Kimmel Foundation for Cancer Research has also funded four cancer centers at San Diego, Memorial Sloan Kettering Cancer Center, Thomas Jefferson University and Johns Hopkins University. The gift to Johns Hopkins, $150 million, is the largest gift ever received by that institution. In the area of arts and culture, The Kimmel Foundation has supported the Kimmel Center for the Performing Arts in Philadelphia as well as the United States Holocaust Memorial Museum in Washington D.C., among others. For more information visit www.kimmel.org.

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Kimmel Foundation Announces 2007 Cancer Research Grant Recipients

FOR IMMEDIATE RELEASE
Contact: Risa B. Hoag, risa@kimmel.org

April 18, 2007 -- The Sidney Kimmel Foundation for Cancer Research has selected fifteen scientists from across the United States to receive two year grants under the Foundation's on-going Scholar program. A total of 145 talented cancer researchers have been provided with grant money since the Foundation's inception with each receiving a $200,000 award to further a specific cancer research project.

The Kimmel Scholar Awards were created in 1997 to further the careers of gifted, young scientists involved in cancer research. Scientists are selected who show the greatest promise and innovation, but whose careers have not been sufficiently advanced to provide them the critical mass of prior research that typically justifies receiving major awards from the National Cancer Institute and other funding sources.

Sidney Kimmel, the organization's founder and chairman ofthe board of Jones Apparel Group and president of Sidney Kimmel Entertainment, meets each year with the Foundation's medical advisory board and observes as the esteemed group of leading cancer doctors narrows down the applicants to the top fifteen. This year there were nearly 200 grant applications for review.

Kimmel, annually selected by BusinessWeek magazine as one of the nation's leading philanthropists, has contributed more than $350 million to cancer centers and cancer research since 1997 and another $100 million to the arts and Jewish continuity.

Many of the exceptional young scientists who have their careers 'jump started' by the Sidney Kimmel Foundation for Cancer Research go on to receive millions of dollars in funding from the NCI and NIH and make significant contributions to the field of cancer research. Many report that they might never have achieved such success without first receiving the Kimmel grant.

This year’s recipients are:

Mary Armanios, M.D.

Kimmel Comprehensive Cancer Center at Johns Hopkins

“Consequences of telomere shortening on stem cell compartments”

Jennifer Cochran, Ph.D.

Stanford University

“Molecular design and engineering of growth factor receptor antagonists for cancer therapy”

Patricia Dahia, M.D., Ph.D.

University of Texas, San Antonio

“Energy Metabolism and Cancer”

Konrad Hochedlinger, Ph.D.

Massachusetts General Hospital

“Analysis of the transcription factor Sox2 in spermatogonial stem cells and germ cell cancer”

Wendong Huang, Ph.D.

Beckman Research Institute of City of Hope

“The role of FXR-dependent bile acid signaling in liver regeneration and hepatocarcinogenesis”

Eric Lai, Ph.D.

Memorial Sloan-Kettering Cancer Center

“Functional analysis of microRNA activity in Drosophila cancer models”

William Matsui, M.D.

Kimmel Comprehensive Cancer Center at Johns Hopkins

“Stem cell regulatory pathways as therapeutic targets in multiple myeloma”

Kathrin Plath, Ph.D.

University of California, Los Angeles School of Medicine

“Function of histone modifications and their enzymes in cancer cells”

Sridhar Ramaswamy, M.D.

Massachusetts General Hospital

“Creating bioactive feeders for cancer discovery”

Michael Rape, Ph.D.

University of California at Berkley

“Regulation of the spindle checkpoint in healthy and in transformed cells”

David Solit, M.D.

Memorial Sloan-Kettering Cancer Center

“Predictors of MEK dependence in RAS and BRAF mutant tumors”

Wenyi Wei, Ph.D.

Beth Israel Deaconess Medical Center

“Identification of novel regulatory mechanisms and substrates for Cdh1 and elucidationof its potential tumor suppressor function”

Jing Yang, Ph.D.

University of California, San Diego

“Dissecting the molecular basis of carcinoma metastasis”

Angela Zarling, Ph.D. University of Virginia

“Targeting of tumor cells utilizing human lymphocytes engineered to express chimeric T cell receptors specific for phosphorylated MHC-restricted antigens”

Rui Zhao, Ph.D.

University of Colorado at Denver

“Targeting the Six1 transcriptional complexes for anti-cancer drug design”

In celebration of the tenth anniversary of The Kimmel Scholar program, Sidney and Caroline Kimmel hosted a weekend long symposium for all Kimmel Scholars and their spouses. More than 200 people attended the affair at which the Kimmels announced their on-going commitment to the future of the Kimmel Scholar program.

The Sidney Kimmel Foundation for Cancer Research has also funded four cancer centers at San Diego, Memorial Sloan Kettering Cancer Center, Thomas Jefferson University and Johns Hopkins University. The gift to Johns Hopkins, $150 million, is the largest gift ever received by that institution. In the area of arts and culture, The Kimmel Foundation has supported the Kimmel Center for the Performing Arts in Philadelphia as well as the United States Holocaust Memorial Museum in Washington D.C., among others. For more information visit www.kimmel.org.

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Kimmel Foundation Announces 2006 Grant Recipients

FOR IMMEDIATE RELEASE
Contact: Risa B. Hoag, risa@kimmel.org

May 8, 2006 -- The Sidney Kimmel Foundation for Cancer Research has selected fifteen scientists from across the United States to receive two year grants under the Foundation's on-going Scholar program. A total of 130 talented cancer researchers have been provided with grant money since the Foundation's inception with each receiving a $200,000 award to further a specific cancer research project. The Kimmel Scholar Awards were created in 1997 to further the careers of gifted, young scientists involved in cancer research. Scientists are selected who show the greatest promise and innovation, but whose careers have not been sufficiently advanced to provide them the critical mass of prior research that typically justifies receiving major awards from the National Cancer Institute and other funding sources.

Sidney Kimmel, the organization's founder and chairman of the board of Jones Apparel Group, meets each year with the Foundation's medical advisory board and observes as the esteemed group of leading cancer doctors narrows down the applicants to the top fifteen. This year there were nearly 200 applications for grants.

Kimmel, selected by BusinessWeek as one of the nation's leading philanthropists, has contributed more than $350 million to cancer centers and cancer research since 1997 and another $100 million to the arts and Jewish continuity.

Many of the exceptional young scientists who have their careers 'jump started' by the Sidney Kimmel Foundation for Cancer Research go on to receive millions of dollars in funding from the NCI and NIH and make significant contributions to the field of cancer research. Many report that they might never have achieved such success without first receiving the Kimmel grant.

This year's Kimmel grant recipients are:

Thijn R. Brummelkamp, Ph.D., Whitehead Institute for Biomedical Research, Cambridge, MA, "Functional characterization of the cancer genome."

Jan A. Burger, M.D., The University of Texas M.D. Anderson Cancer Center, Houston, TX, "Cross talk between the B-cell receptor and CXCR-4 chemokine receptors in chronic lymphocytic leukemia: a newrole for ZAP-70."

Shridar Ganesan, M.D., Cancer Institute of New Jersey, New Brunswick, NJ, "Biology of human basal-like breast cancers."

Or Gozani, M.D., Ph.D., Stanford University, Stanford, CA, "ING proteins: linking chromatin modulation to tumor suppression."

Amy A. Kiger, Ph.D., University of California, San Diego, CA, "Roles and regulation of myotubularin-dependent phosphoinositide pathways in cellular differentiation."

Andrew L. Kung, M.D., Ph.D., Dana-Farber Cancer Institute, Boston, MA, "Tumor hypoxia: mechanisms of adaptation and opportunities for therapeutic targeting."

Ming Lei, Ph.D., University of Michigan, Ann Arbor, MI, "Structural studies of single-stranded telomeric DNA and its binding protein POT1."

Loren Michel, M.D., Washington University in St. Louis, St. Louis, MO, "Validating the Trop-2 receptor as a target for anti-cancer therapy."

Yanhong Shi, Ph.D., Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, "The role of nuclear receptor TLX signaling in brain tumors."

Kimberly Stegmaier, M.D., Dana-Farber Cancer Institute, Boston, MA, "Modulating the 'undruggable' oncoprotein with signature-based small molecule library screening."

E. Alejandro Sweet-Cordero, M.D., Stanford University, Stanford, CA, "Functional genomic analysis of oncogenic K-ras signaling."

David Traver, Ph.D., University of California, San Deigo, CA, "The role of Runx1 in normal and neoplastic hematopoiesis."

Nicola Zanesi, Ph.D., Ohio State University, Columbus, OH, "Mouse models of the most common human cancers."

Xianzheng Zhou, M.D., Ph.D., The University of Minnesota, Minneapolis, MN, "Adoptive T-Cell therapy of leukemia by the Sleeping Beauty transposon."

Sandra S. Zinkel, M.D., Ph.D., Vanderbilt University, Nashville, TN, "The role of proapoptotic BID in mediating apoptosis and the DNA damage response in myeloid homeostasis and leukemogenesis."

In addition to the Kimmel Scholar Program, the Sidney Kimmel Foundation for Cancer Research has funded four cancer centers at San Diego, Memorial Sloan Kettering Cancer Center, Thomas Jefferson University and Johns Hopkins University. The gift to Johns Hopkins, $150 million, is the largest gift ever received by that institution. In the area of arts and culture, The Kimmel Foundation has supported the Kimmel Center for the Performing Arts in Philadelphia as well as the United States Holocaust Memorial Museum in Washington D.C., among others.

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SIDNEY KIMMEL RECEIVES FIRST-EVER MEDAL OF HONOR FOR CANCER PHILANTHROPY FROM THE AMERICAN CANCER SOCIETY

FOR IMMEDIATE RELEASE
Contact: Risa B. Hoag, risa@kimmel.org

BALTIMORE, January 5, 2006 — The American Cancer Society recently presented its highest honor, the Medal of Honor, to three Americans who have made outstanding contributions to the fight against cancer. Sidney Kimmel received the Society’s first-ever Medal of Honor for Cancer Philanthropy.

Sidney Kimmel was honored for “his vision in improving the understanding of cancer biology, treatment, and prevention, hisdemonstrative leadership to change our government’s commitment to fighting cancer, his unparalleled contributions to cancer research and care through the Sidney Kimmel Foundation and the Sidney Kimmel Foundation for Cancer Research, his generoussupport of the American Cancer Society’s lifesaving mission, and his dedication to promoting groundbreaking cancer research and improvements in the quality of life of cancer patients.” The two other awardees at the November 18th event were Walter C. Willett, MD, DrPH, who received the Medal of Honor for Clinical Research, and Paul L. Modrich, PhD, who received the Medal of Honor for Basic Research.

Kimmel has directed his success, spanning nearly five decades in the garment industry, into a remarkable personal effort to eliminate cancer as a major health problem. In the mid 1950’s after attending Temple University and completing two tours of duty in the U.S. Army, Mr. Kimmel was employed by a Philadelphia-based fashion firm, Villager, overseeing the knitwear line – its fastest growing division – and eventually becoming president. In 1970 he founded Jones New York, which has grown into a Fortune 500 company with sales now exceeding $5 billion. Kimmel founded the Sidney Kimmel Foundation and its subsidiary, the Sidney Kimmel Foundation for Cancer Research, in 1993 and since that time has awarded more than $450 million to various philanthropic causes primarily in the areas of cancer research, the performing arts, and Jewish continuity.

The Sidney Kimmel Foundation for Cancer Research funds the Kimmel Scholars Program which annually presents 15 of the most promising young cancer researchers with a $200,000 stipend for cancer research in path-breaking areas. To date 115 Scholars have received this prestigious grant.

Sidney Kimmel’s dedication to solving the mysteries of cancer also includes inspiring and funding the 1998 march on Washington to lobby Congress for enhanced funding for cancer research which produced very successful results by doubling grants to the National Cancer Institute.

Through the Sidney Kimmel Foundation, Kimmel has contributed to several health care organizations including The Sidney Kimmel Comprehensive CancerCenter at Johns Hopkins, Baltimore; the Kimmel Cancer Center at Thomas Jefferson University, Philadelphia; the Sidney Kimmel Cancer Center, San Diego; and Memorial Sloan-Kettering Cancer Center, New York. In addition Kimmel is likely the single biggest donor to cancer research in the United States with total commitments exceeding $300 million. He is recognized each year by BusinessWeek as one of the nation's most generous philanthropists.

In his acceptance speech Mr. Kimmel commented, “when it comes to cancer the time has come to lessen the grip of ego, to expand cooperation and reduce duplication, and the time has come to redouble the effort to get government committed to specific goals and advancements.” He called for a “self-effacing dialogue and development of vision embodied with very specific goals, cooperation, efficiency and leadership.”

Among his many awards, Kimmel has also received the American Cancer Society's Humanitarian Award, the American Jewish Committee's National Human Relations Award, and the Musser Award for Excellence in Leadership from Temple University. For more information about The Sidney Kimmel Foundation visit www.kimmel.org.

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SIDNEY KIMMEL FOUNDATION FOR CANCER RESEARCH ANNOUNCES 2005 GRANT RECIPIENTS

FOR IMMEDIATE RELEASE
Contact: Risa B. Hoag, risa@kimmel.org

April 26, 2005 – Fifteen exceptional scientists have received significant grants from The Sidney Kimmel Foundation for Cancer Research. The impressive group of scholars from nine states will each receive a two year, $200,000 award to further their cancer research projects.

The Kimmel Scholar Awards were created in 1997 to further the careers of young, gifted physicians and Ph.Ds involved in cancer research. Scientists are selected who show the greatest promise and innovation, but whose careers have not been sufficiently advanced to provide them the critical mass of research history that typically justifies receiving major grants from the National Cancer Institute and other funding sources.

Todate the Foundation has supported 115 scholars. Sidney Kimmel, the organization’s founder and chairman of the board of Jones Apparel Group, meets each year with the Foundation’s medical advisory board and observes as the esteemed group of leading cancer doctors narrows down the applicants to the top fifteen.

“What makes this year different from past years is the tremendous increase in requests for grants,” states Dr. Gary Cohen, Administrative Director of The Sidney Kimmel Foundation for Cancer Research. While the number of applications has remained relatively steady over the past several years, this year’s submissions jumped by 25%, believed to be due in part to the government’s inability to keep up with the demand and need for funding.

“Young scientists are not getting the support they need to develop better means of cancer diagnosis, treatment and prevention and that funding needs to be a major government priority,” added Dr. Cohen. According to recently published reports, cancer has surpassed heart disease as the leading cause of death among Americans under the age of 85 making funding for new research and clinical trials even moreimperative.

Kimmel, selected again this year by BusinessWeek as one of the nation’s leading philanthropists, has contributed more than $350 million to cancer centers and cancer research since 1997 and another $100 million to the arts and Jewish continuity.

Many of the exceptional young scientists who have theircareers ‘jump started’ by the Sidney Kimmel Foundation for Cancer Research go on to receive millions of dollars in funding from the NCI and NIH and make significant contributions to the field of cancer research. Many report that they might never have achieved such success without first receiving the Kimmel grant.

This year’s Kimmel grant recipients are:

Iannis Aifantis, Ph.D.: University of Chicago, “Mechanisms of notch-induced T Cell Leukemia”

Rami Aqeilan, Ph.D.: The Ohio State University Research Foundation, “The Role of WWOX tumor suppressor gene in cancer”

Catherine Bollard, M.D.: Baylor College of Medicine, “Overcoming tumor immune evasion strategies in lymphoma”

Ruben Carrasco, M.D., Ph.D.: Dana-Farber Cancer Institute, “Genetic models and translational studies of multiple myeloma”

Sandy Chang, M.D., PhD.: University of Texas M.D. Anderson Cancer Center, “Molecular mechanisms controlling the alternative lengthening of telomeres pathway”

Patricia Ernst, Ph.D.: Dartmouth College, “MII-dependent pathways in normal and leukemic hematopoiesis”

Dmitry Fyodorov, Ph.D.: Albert Einstein College of Medicine, “Biochemistry and genetics of chromatin assembly”

Lucy Godley, M.D., Ph.D.: University of Chicago, “The role of DNMT3B in mediating the abnormal DNA methylation patterns in cancer cells”

Johanna Joyce, Ph.D.: Memorial Sloan Kettering Cancer Center, “Genetic analysis of the cysteine cathepsin family of proteases during multistage tumor development”

Chang Kim, Ph.D.: Purdue University, “Identification of trafficking signals important for cancer cell interaction with regulatory T cells”

Anthony Letai, M.D., Ph.D.: Dana-Farber Cancer Institute, “Targeting apoptotic defects in cancer”

Gary Luker, M.D.: University of Michigan, “Imaging CXCR4 in primary and metastatic breast cancer”

Toru Nakamura, Ph.D.: University of Illinois at Chicago, “Roles of checkpoint proteins and chromatin modifications in genome stability, DNA repair and telomere maintenance”

Joel Pomerantz, Ph.D.: The Johns Hopkins University School of Medicine, “The identification of targets for the treatment of NF-kB-dependent cancers”

David Watkins, M.D., Ph.D.: The Johns Hopkins University School of Medicine, “Basic and preclinical investigation of aberrant hedgehog signaling in cancer”

In addition to the Kimmel Scholar Program, the Sidney Kimmel Foundation for Cancer Research has funded four cancer centers atSan Diego, Memorial Sloan Kettering Cancer Center, Thomas Jefferson University and Johns Hopkins University. The gift to Johns Hopkins, $150 million, is the largest gift ever received by that institution. In the area of arts and culture, The Kimmel Foundation has supported the new Kimmel Center for the Performing Arts as well as the United States Holocaust Memorial Museum among others.

For more information about this year’s scholars or the Sidney Kimmel Foundation for Cancer Research, contact Risa Hoag at risa@kimmel.org or visit www.kimmel.org.

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SIDNEY KIMMEL FOUNDATION FOR CANCER RESEARCH REPORTS 25% INCREASE IN GRANT APPLICATIONS; FOUNDATION TO SELECT 15 NEW SCHOLARS SPRING 2005

FOR IMMEDIATE RELEASE
Contact: Risa B. Hoag, risa@kimmel.org

February 23, 2005 – When the medical advisory board of the Sidney Kimmel Foundation for Cancer Research convenesearly this spring, they will select fifteen new Kimmel Scholars bringing the total funded to date to 115 since the program’s inception in 1997.

“What makes this year different from past years is the tremendous increase in requests for grants,” states Dr. Gary Cohen, Administrative Director of The Sidney Kimmel Foundation for Cancer Research. “The number of applications has remained relatively steady, but we had a significant 25% increase this year. We believe this is due in part to the government’s inability to keep up with the demand and need for funding. The work of these young scientists, to develop better means of cancer diagnosis, treatment and prevention, needs to be a major government priority," states Dr. Cohen.

According to recently published reports, cancer has passed heart disease as the leading cause of death among Americans under the age of 85 making funding for new research and clinical trials even more imperative. And while campaigns such as Lance Armstrong’s Live Strong, have brought attention to the need for better funding, few new sources of funds have emerged.

Entrepreneur and philanthropist Sidney Kimmel, distributes $3 million each year to young scientists for specific and innovative cancer research projects. Scientists chosen must not have been approved yet for traditional government funding. Kimmel’s philosophy behind this requirement is that he is able to help those young but brilliant scientists who clearly need a leg up to get their labs started, and in fact a vast majority go on to receive more traditional funding after receiving a Kimmel grant.

“We believe that it is the young scientists who think ‘outside the box’ that hold the promise of someday converting cancer into a chronic disease rather than a death sentence,” states Sidney Kimmel, founder and Chairman of the Board of Jones Apparel Group. Mr. Kimmel’s dedication to solving the mysteries of cancer also includes inspiring and funding the 1998 march on Washington to lobby Congress for enhanced funding for cancer research which produced very successful results by doubling grants to the National Cancer Institute.

Each Kimmel scholar receives a $200,000 stipend over a two year period and must perform his or her research in an American not-for-profit institution. Each awardee submits an application detailing aspecific project and how it is expected to impact an area of cancer research. Selections are made by a medical advisory board comprised of thirteen of the nation’s most renowned cancer researchers.

The Sidney Kimmel Foundation has also funded four cancer centers at San Diego, Memorial Sloan Kettering Cancer Center, Thomas Jefferson University and Johns Hopkins University. Sidney Kimmel is likely the single biggest donor to cancer research in the United States with total commitments esceeding $300 million to date. He is recognized each year by BusinessWeek as oneof the nation's most generous philanthropists.

For more information about The Sidney Kimmel Foundation for Cancer Research contact Risa Hoag at risa@kimmel.org or visit www.kimmel.org.

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KIMMEL FOUNDATION AWARDS FIFTEEN CANCER RESEARCHERS GRANTS FOR INNOVATIVE APPROACHES TO FIGHT CANCER Kimmel Scholars now total 100

FOR IMMEDIATE RELEASE
Contact: Risa B. Hoag, risa@kimmel.org

MARCH 29, 2004 – The final review process took nearly seven hours, but the thirteen member medical advisory board of The Sidney Kimmel Foundation for Cancer Research emerged from their annual conference with the names of fifteen new Kimmel Scholars bringing the total number selected since 1997 to 100. The Kimmel Scholar Awards are designed to further the careers of some of the youngest and brightest minds doing cancer research today. Each Kimmel Scholar will receive a $200,000 grant over a two year period.

conference

"This is my favorite day of the year," said Sidney Kimmel, the organization’s founder and chairman of the board of Jones Apparel Group. "It gives me great joy to listen to these accomplished doctors discuss the merits of each research project until they narrow it down to those who are likely to make the most innovative contributions to cancer research," he added.

Kimmel, consistently ranked by Business Week as one of the top 15 most generous philanthropist in the United States, has contributed more than $350 million to cancer centers and cancer research since 1997 and another $100 million to the arts and Jewish continuity.

In choosing the newest scholars, the medical advisory board, made up of some of the top cancer doctors in their fields today, ask questions such as "Is the science sound? How many others are working in this area of research? What scientific journals have published their work?” It is a task that requires more than 40 hours of review time from each board member before the annual selection meeting.

"Our reviews for Kimmel Scholars do not in any way take into account gender or ethnicity or nationality. All that matters is the science. But after the decisions were made, it was nice to note that the two proposals with the best reviews were from a young female scientist and from a young Hispanic male scientist," noted Kimmel Medical Advisory Board member Dr. Mary-ClaireKing who is also an American Cancer Society Professor at the University of Washington School of Medicine in Seattle.

Sidney Kimmel attends the conference every year and while he does not participate in the actual selection process, he closely reviews each of the potential candidates' material during the all-day meeting. "Iam grateful that I am fortunate enough to be able to help these brilliant scientists," said Kimmel.

"These are Sidney's 'grant-children’” said Dr. Web Cavenee, medical advisory board member and Director of the Ludwig Institute for Cancer Research at the University of California-San Diego. “It is an extraordinary thing he's doing, contributing to science and society in this way, jump-starting the careers of these exceptional young scientists many of whom have gone on to receive millions of dollars in funding from the NCI and NIH and make significant contributionsto the field of cancer research. And many report that they might never have achieved such success without Sidney's grant at the most critical time in theircareer," Dr. Cavenee added.

The 100 scholars have hailed from 52 different institutions across the United States since 1997 including nine from Harvard Medical School/Dana Farber Cancer Institute, eight from Johns Hopkins University School of Medicine/Sidney Kimmel Comprehensive Cancer Center, seven from The Sidney Kimmel Cancer Center at Thomas Jefferson University and seven from Duke University Medical Center. This year’s Kimmel Grant winners are:

IVAN BORRELLO, MD - Sidney Kimmel Cancer Institute, JohnsHopkins University: “Strategies to enhance tumor-specific immunotherapy in multiple myeloma”

SCOTT BRIGGS, PhD - Purdue University: “Functional characterization of the multiple myeloma SET domain protein (MMSET)”

GEORGE CALIN, MD, PhD - Kimmel Cancer Center, ThomasJefferson University: “The role of micro RNAs in human cancer development”

DIEGO CASTRILLON, MD, PhD - University of Texas,Southwestern Medical Center (Dallas): “Genetic model systems and translational studies of endometrial cancer”

JAMES CHEN, PhD - Stanford University School of Medicine: “Chemical and genetic studies of the hedgehog pathway”

DAVID FERGUSON, MD, PhD - University of Michigan, Ann Arbor: “Genomic instability incancer: mechanisms of gene amplification and roles of Mre11”

DANIEL KAMEI, PhD - University of California, Los Angeles: "Increasing the half-lives of angiogenesis inhibitors using systems-level analyses"

CLARA KIELKOPF, PhD - Johns Hopkins University: "Structural basis of normal pre-mRNA splice site recognition and its dysfunction in neoplasia"

HARMET MALIK, PhD- Fred Hutchinson Cancer Research Center: "Is genetic conflict responsible for centromere complexity?"

JEFFREY RATHMELL, PhD - Duke University Medical Center: "Cell survival and glucose uptake in cancer and autoimmunity"

JEREMY RICH, MD - Duke University Medical Center: "Transforming growth factor beta signaling and targeting in malignant gliomas"

BRIAN SCHAEFER, PhD - Uniformed Services University of the Health Sciences: "Role of NF-kB signaling intermediates in the etiology of MALT lymphoma"

SHEILA STEWART, PhD - Washington University: "Molecular mechanisms of cellular immortality"

KWOK-KIN WONG, MD, PhD - Dana Farber Cancer Institute: "The genetic role of telomere dynamics and DNA damage response in cancer and aging"

YIHUA YU, PhD - University of Utah: "An integrated docking/imaging device for cancer radioimmunotherapy"

Kimmel Scholars are some of the most gifted doctors involved in cancer research today. Mr. Kimmel's thinking was to provide research grants to applicants showing the greatest promise and innovation but whose careers have not been sufficiently advanced to provide them the critical mass of research history that typically justifies receiving grants from the National Cancer Institute and other funding sources.

The Sidney Kimmel Foundation has also funded four cancer centers at San Diego, Memorial Sloan Kettering Cancer Center, Thomas Jefferson University and Johns Hopkins University. The gift to Johns Hopkins, $150 million, is the largest gift ever received by that institution. In the area of arts and culture, The Kimmel Foundation has supported the new Kimmel Center for the Performing Arts as well as the United States Holocaust Memorial Museum among others.

For more information about this year's scholars or The Sidney Kimmel Foundation for Cancer Research, contact Risa Hoag at 845-627-3000 or visit www.kimmel.org.

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SIDNEY KIMMEL FOUNDATION FOR CANCER RESEARCH WILL SELECT 100TH GRANT RECIPIENT MARCH 2004

FOR IMMEDIATE RELEASE
Contact: Risa B. Hoag, risa@kimmel.org

February 19, 2004 – When the medical advisory board of the Sidney Kimmel Foundation for Cancer Research convenes in March, they will choose fifteen new Kimmel Scholars bringing the total number funded to date to100 since theprogram’s inception in 1997. Each scholar, who will receive a $200,000 grant over a two year period, must perform his or her research in an American not-for-profit institution and submit an application detailing the specific project and how it is expected to impact an area of cancer research.

The Kimmel Scholar Awards are designed to further the careers of someof the youngest and brightest minds doing cancer research today. Mr. Kimmel’s thinking was to provide research grants to applicants showing the greatest promise and innovation but whose careers have not been sufficiently advanced to provide them the critical mass of research history that typically justifies receiving grants from the National Cancer Institute and other funding sources.

Selections aremade by a medical advisory board comprised of 13 of the nation’s most renowned cancer researchers. This year the Board has received over 150 applications for the awards; five will be chosen to receive grants for translational research which are studies that integrate clinical and laboratory investigations in either humans or animals, and the remaining grants will be for basic research.

The Sidney Kimmel Foundation has also funded four cancer centers at San Diego, Memorial Sloan Kettering Cancer Center, Thomas Jefferson University and Johns Hopkins University. The gift to Johns Hopkins, $150 million to establish the Sidney Kimmel Comprehensive Cancer Center, is the largest gift ever received by that institution. In fact, Mr. Kimmel is likely the single biggest donor to cancer research in the United States with total commitments exceeding $300 million to date.

Mr. Kimmel’s dedication to solving the mysteries of cancer also includes inspiring and funding a 1998 march on Congress to lobby for augmented funding for cancer research which produced very successful results by doubling the grants to the National Cancer Institute.

Last year’s grant recipients hailed from nine states and eleven different universities including Dana-Farber Cancer Institute, Johns Hopkins University School of Medicine, Harvard University, Purdue University, Duke University School of Medicine, University of Texas Health Science Center, University of North Carolina at Chapel Hill, Ohio State University and Thomas Jefferson University, University of California and the Albert Einstein College of Medicine.

Sidney Kimmel is the founder and Chairman of Jones Apparel Group and has awarded more than $420 million to various philanthropic causes through the Sidney Kimmel Foundation, primarily in the areas of cancer research, the performing arts and Jewish continuity.

In the area of arts and culture, The Kimmel Foundation has supported the new Kimmel Center for the Performing Arts,designed by Rafael Vinoly and home of the world-class Philadelphia Orchestra, aswell as the United States Holocaust Memorial Museum among others. Mr. Kimmel is recognized repeatedly by Business Week as one of the nation's top most generous philanthropists.

For more information about The Sidney Kimmel Foundation for Cancer Research contact Risa Hoag at 845-627-3000 or visit www.kimmel.org.

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News Media: If you would like to speak with a Kimmel Scholar or Advisory Board Member or would like digital photographs, please contact Risa B. Hoag at 845-627-3000 or at risa@gmgpr.com.

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