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2009 KIMMEL SCHOLAR AWARDEES
*Valerie Brown, M.D., Ph.D.
Children's Hospital of Philadelphia
Preclinical evaluation of targeting the mTOR signaling network in acute lymphoblastic leukemia
Paul Chang, Ph.D.
Massachusetts Institute of Technology
New PARP isoforms for cancer therapies
Lara Collier, Ph.D.
University of Wisconsin, Madison
Genetic approaches to studying glioma formation and therapy resistance
Muller Fabbri, M.D.
Ohio State University Research Foundation
Role of p53 regulation of microRNAs and ultraconserved regions in human cancer
Danica Galonic Fujimori, Ph.D.
University of California, San Francisco
Histone-modifying enzymes in cancer: elucidating roles of histone demethylases
* Erich Huang, M.D., Ph.D.
Duke University Medical Center
Oncogenic network interrogation for elucidating colon cancer tumorigenesis and identifying novel combination therapies
Terry Lechler, Ph.D.
Duke University Medical Center
Mechanism of asymmetric cell divisions and their role in tumor supression
* Alexander Minella, M.D.
Northwestern University Feinberg School of Medicine
Deregulated cell cycle controls in the pathogenesis of hematopoietic cancers
* Sohail Tavazoie M.D., Ph.D.
Rockefeller University
Dissecting the mechanisms that regulate the expression of human metastasis suppressor microRNAs
Andrea Ventura, M.D., Ph.D.
Memorial Sloan Kettering Cancer Center
Functional analysis of the miR-17~92 family of oncogenic miRNA clusters
Bin Wang, Ph.D.
M.D. Anderson Cancer Center
Functional analysis of new regulatory components in BRCA1 signaling and tumor suppression
Zefeng Wang, Ph.D.
University of North Carolina at Chapel Hill
Engineering artificial splicing factors with designed specificities as new cancer treatments
* Translational Scholars
2008 KIMMEL SCHOLAR AWARDEES
Nabeel Bardeesy, Ph.D.
Massachusetts General Hospital
Function of the WTX tumor suppressor
*Barbara Buttin, M.D.
Northwestern University
The role of synuclein-gamma (SNCG)in the carcinogenesis of uterine papillary serous carcinoma
Richard Gardner, Ph.D.
University of Washington
Understanding the roles of protein deubiquitination in chromatin regulation and other vital nuclear processes
* Ramiro Garzon, M.D.
Ohio State University
Epigenetic modulation of DNA methyltransferases by miR-29b: a paradigm for developing novel hypomethylating strategies in AML
* Roger Greenberg, M.D., Ph.D.
University of Pennylsvania School of Medicine
Control of homologous recombination at DNA double strand break sites by manipulating lysine-63-linked ubiquitin metabolism
Patrick Hu, M.D., Ph.D.
University of MIchigan
Novel regulators of FoxO tumor supressors
Tae Hoon Kim, Ph.D.
Yale University
Genome-wide analysis of chrom
Karen Liby, Ph.D.
Darthmouth Medical School
New drugs and drug combinations for the prevention and treatment of cancer
* Ingo Mellinghoff, M.D.
Memorial Sloan-Kettering Cancer Center
Overcoming PTEN-associated resistance of EGFR kinase
Raul Mostoslavsky, M.D., Ph.D.
Massachusetts General Hospital
The role of the SIRT6 chromatin factor in DNA repair and in metabolic homeostasis
Cathie Pfleger, Ph.D.
Mount Sinai School of Medicine
Identification and chracterization of mutations in non-tumor cells that promote metastasis
Jeroen Roose, Ph.D.
University of California, San Francisco
Increased RasGRP1 function leads to aberrantly sensitized Ras activation and development of T cell lymphomas in humans
Lanlan Shen, M.D., Ph.D.
University of Texas, M.D. Anderson Cancer Center
Epiteneticreprogramming in cancer
Hengbin Wang, Ph.D.
University of Alabama, Birmingham
Role of Ubp-M and H2A deubiquitination in breast cancer development
* Jen Jen Yeh, M.D.
University of North Carolina at Chapel Hill
Identification and validation of novel targets for the treatment of pancreativ cancer using a prognostic gene signature
Hang Yin, Ph.D.
University of Colorado, Boulder
Novel peptide probes to study the activation mechanism of the Epstein-Barr Virus latent membrane protein 1
* Translational Scholars
2007 KIMMEL SCHOLAR AWARDEES
*Mary Armanios, M.D.
Kimmel Comprehensive Cancer Center at Johns Hopkins
Consequences of telomere shortening on stem cell compartments
Jennifer Cochran, Ph.D.
Stanford University
Molecular design and engineering of growth factor receptor antagonists for cancer therapy
*Patricia Dahia, M.D., Ph.D.
University of Texas, San Antonio
Energy Metabolism and Cancer
Konrad Hochedlinger, Ph.D.
Massachusetts General Hospital
Analysis of the transcription factor Sox2 in spermatogonial stem cells and germ cell cancer
Wendong Huang, Ph.D.
Beckman Research Institute of City of Hope
The role of FXR-dependent bile acid signaling in liver regeneration and hepatocarcinogenesis
Eric Lai, Ph.D.
Memorial Sloan-Kettering Cancer Center
Functional analysis of microRNA activity in Drosophila cancer models
*William Matsui, M.D.
Kimmel Comprehensive Cancer Center at Johns Hopkins
Stem cell regulatory pathways as therapeutic targets in multiple myeloma
Kathrin Plath, Ph.D.
University of California, Los Angeles School of Medicine
Function of histone modifications and their enzymes in cancer cells
*Sridhar Ramaswamy, M.D.
Massachusetts General Hospital
Creating bioactive feeders for cancer discovery
*David Solit, M.D.
Memorial Sloan-Kettering Cancer Center
Predictors of MEK dependence in RAS and BRAF mutant tumors
Wenyi Wei, Ph.D.
Beth Israel Deaconess Medical Center
Identification of novel regulatory mechanisms and substrates for Cdh1 and elucidation of its potential tumor suppressor function
Jing Yang, Ph.D.
University of California, San Diego
Dissecting the molecular basis of carcinoma metastasis
Angela Zarling, Ph.D.
University of Virginia
Targeting of tumor cells utilizing human lymphocytes engineered to express chimeric T-cell receptors specific for phosphorylated MHC-restricted antigens
Rui Zhao, Ph.D.
University of Colorado at Denver
Targeting the Six1 transcriptional complexes for anti-cancer drug design
* Translational Scholars
2006 Kimmel Scholar Awardees
Thijn R. Brummelkamp, Ph.D.
Whitehead Institute for Biomedical Research
Functional characterization of the cancer genome
Jan A. Burger, M.D.
The University of Texas M.D. Anderson Cancer Center
Cross talk between the B-cell receptor and CXCR-4 chemokine receptors in chronic lymphocytic leukemia: a new role for ZAP-70
Shridar Ganesan, M.D.
Cancer Institute of New Jersey
Biology of human basal-like breast cancers
Or Gozani, M.D., Ph.D.
Stanford University
ING proteins: linking chromatin modulation to tumor suppression
Amy A. Kiger, Ph.D.
University of California
Roles and regulation of myotubularin-dependent phosphoinositide pathways in cellular differentiation
Andrew L. Kung, M.D., Ph.D.
Dana-Farber Cancer Institute
Tumor hypoxia: mechanisms of adaptation and opportunities for therapeutic targeting
Ming Lei, Ph.D.
University of Michigan
Structural studies of single-stranded telomeric DNA and its binding protein POT1
Loren Michel, M.D.
Washington University in St. Louis
Validating the Trop-2 receptor as a target for anti-cancer therapy
Yanhong Shi, Ph.D.
Beckman Research Institute, City of Hope National Medical Center
The role of nuclear receptor TLX signaling in brain tumors
Kimberly Stegmaier, M.D.
Dana-Farber Cancer Institute
Modulating the ‘undruggable’ oncoprotein with signature-based small molecule library screening
E. Alejandro Sweet-Cordero, M.D.
Stanford University
Functional genomic analysis of oncogenic K-ras signaling
David Traver, Ph.D.
University of California
The role of Runx1 in normal and neoplastic hematopoiesis
Nicola Zanesi, Ph.D.
Ohio State University
Mouse models of the most common human cancers
Xianzheng Zhou, M.D., Ph.D.
The University of Minnesota
Adoptive T-Cell therapy of leukemia by the Sleeping Beauty transposon
Sandra S. Zinkel, M.D., Ph.D.
Vanderbilt University
The role of proapoptotic BID in mediating apoptosis and the DNA damage response in myeloid homeostasis and leukemogenesis
2005 Kimmel Scholar Awardees
Iannis Aifantis, Ph.D.
University Of Chicago
Mechanisms of Notch-Induced T Cell Leukemia
Rami Aqeilan, Ph.D.
The Ohio State University Research Foundation
The Role of WWOX Tumor Suppressor Gene in Cancer
Catherine Bollard, M.D.
Baylor College of Medicine
Overcoming Tumor Immune Evasion Strategies in Lymphoma
Ruben Carrasco, M.D., Ph.D.
Dana-Farber Cancer Institute
Genetic Models and Translational Studies of Multiple Myeloma
Sandy Chang, M.D., Ph.D.
University of Texas M.D. Anderson Cancer Center
Molecular Mechanisms Controlling the Alternative Lengthening of Telomeres Pathway
Patricia Ernst, Ph.D.
Dartmouth College
MII-Dependent Pathways in Normal and Leukemic Hematopoiesis
Dmitry Fyodorov, Ph.D.
Albert Einstein College ofMedicine
Biochemistry and Genetics of Chromatin Assembly
Lucy Godley, M.D., Ph.D.
University Of Chicago
The Role Of DNMT3B in Mediating The Abnormal DNA Methylation Patterns in Cancer Cells
Johanna Joyce, Ph.D.
Memorial Sloan Kettering Cancer Center
Genetic Analysis of the Cysteine Cathepsin Family of Proteases During Multistage Tumor Development
Chang Kim, Ph.D.
Purdue University
Identification of Trafficking Signals Important for Cancer Cell Interaction ith Regulatory T Cells
Anthony Letai, M.D., Ph.D.
Dana-Farber Cancer Institute
Targeting Apoptotic Defects in Cancer
Gary Luker, M.D.
University Of Michigan
Imaging CXCR4 in Primary and Metastatic Breast Cancer
Toru Nakamura, Ph.D.
University of Illinois at Chicago
Roles of Checkpoint Proteins and Chromatin Modifications in Genome Stability, DNA Repair and Telomere Maintenance
Joel Pomerantz, Ph.D.
The Johns Hopkins University School of Medicine
The Identification of Targets for the Treatment of NF-Kb-DependentCancers
David Watkins, M.D., Ph.D.
The Johns Hopkins University School of Medicine
Basic and Preclinical Investigation of Aberrant Hedgehog Signaling In Cancer
2004 Kimmel Scholar Awardees
Ivan Borrello, M.D.
SidneyKimmel Cancer Institute, Johns Hopkins University
Strategies to Enhance Tumor-Specific Immunotherapy in Multiple Myeloma
Scott Briggs, Ph.D.
Purdue University
Functional Characterization of The Multiple Myeloma SET Domain Protein (MMSET)
George Calin, M.D., Ph.D.
Kimmel Cancer Center, Thomas Jefferson University
The Role of Micro RNAs In Human Cancer Development
Diego Castrillon, M.D., Ph.D.
University of Texas, Southwestern Medical Center (Dallas)
Genetic Model Systems and Translational Studies of Endometrial Cancer
James Chen, Ph.D.
Stanford University School of Medicine
Chemical and Genetic Studies of the Hedgehog Pathway
David Ferguson, M.D., Ph.D.
University Of Michigan, Ann Arbor
Genomic Instability in Cancer Mechanisms of Gene Amplification and Roles Of Mre11
Daniel Kamei, Ph.D.
University Of California, Los Angeles
Increasing the Half-Lives of Angiogenesis Inhibitors Using Systems-Level Analyses
Clara Kielkopf, Ph.D.
Johns Hopkins University
Structural Basis Of Normal Pre-Mrna Splice Site Recognition and Its Dysfunction In Neoplasia
Harmet Malik, Ph.D.
Fred Hutchinson Cancer Research Center
Is Genetic Conflict Responsible for Centromere Complexity?
Jeffrey Rathmell, Ph.D.
Duke University Medical Center
Cell Survival and Glucose Uptake in Cancer and Autoimmunity
Jeremy Rich, M.D.
Duke University Medical Center
Transforming Growth Factor Beta Signaling and Targeting In Malignant Gliomas
Brian Schaefer, Ph.D.
Uniformed Services University of The Health Sciences
Role Of NF-Kb Signaling Intermediates In The Etiology Of MALT Lymphoma
Sheila Stewart, Ph.D.
Washington University
Molecular Mechanisms of Cellular Immortality
Kwok-Kin Wong, M.D., Ph.D.
Dana Farber Cancer Institute
The Genetic Role of Telomere Dynamics and DNA Damage Response in Cancer And Aging
Yihua Yu, Ph.D.
University Of Utah
An Integrated Docking/Imaging Device for Cancer Radioimmunotherapy
2003 Kimmel Scholar Awardees
Joanne Chan, Ph.D.
Children's Hospital, Boston
Genetic dissection of angiogenesis in the zebrafish
Nancy DeMore, M.D.
University of North Carolina at Chapel Hill
Molecular mechanisms controlling human tumor dormancy
Nicholas Gaiano, Ph.D.
Johns Hopkins University
The regulation of neural stem cell proliferation by notch and FGF signaling
David Jeruzalmi, Ph.D.
Harvard University
Structure and function of the mini-chromosome maintenance (MCM) assembly
Ann L. Kirchmaier, Ph.D.
Purdue University
Epigenetic regulation of Epstein-Barr viralgene expression
Motonari Kondo, M.D., Ph.D.
Duke University
Lineage infidelity: relationship between plasticity of lymphoid progenitors and leukemogenesis
Sang Eun Lee, Ph.D.
University of Texas, San Antonio
Role of chromatin remodeler in repair of damaged DNA
Mark Levis, M.D., Ph.D.
Johns Hopkins University
Targeting FLT3 as a novel, specific therapy for leukemia
Linda Liau, M.D., Ph.D.
University of California, Los Angeles
Characterization of GDOX, a novel putative oncogene preferentially expressed in human glioma
Ari Melnick, M.D.
Albert Einstein College of Medicine
Development of structure-guided molecular targeted transcription therapy for b-cell lymphoma
Akhilesh Pandey, M.D., Ph.D.
Johns Hopkins University School of Medicine
Molecular dissection of EGF receptor signal transduction
Roberto Pili, M.D.
Johns Hopkins University
Novel combination therapy targeting tumor angiogenesis with chromatin remodeling agents
Norman Sharpless, M.D.
University of North Carolina at Chapel Hill
The regulation of the tumor suppressor p16INK4a in cancer and aging
Said Sif, Ph.D.
Ohio State University
Role of histone methyltransferase-containing human SWI/SNF complexes in cancer
Srinivasa Srinivasula, Ph.D.
Thomas Jefferson University
Characterization of caspase linker domain(s)
Robert Wechsler-Reya, Ph.D.
Duke University
The molecular basis of childhood brain tumors |
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