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2010 KIMMEL SCHOLAR AWARDEES

 

* Maximillian Diehn, M.D., Ph.D.

Stanford University School of Medicine

Exploring Metabolic Properties of Tumor Initiating Cells

 

Matthew Gamble, Ph.D.

Albert Einstein College of Medicine

Exploring the interplay between macro domains and poly (ADP-ribose) polymerases in tumor progression and suppression

 

Zev Gartner, Ph.D.

University of California, San Francisco

Unraveling the relationship between tissue structure and cancer progression

 

* Rani George, M.D., Ph.D.

Dana-Farber Cancer Institute

Functional analysis of ALK mutations in neuroblastoma

 

A. McGarry Houghton, M.D.

University of Pittsburgh

IRS1-Mediated Regulation of P13K and MEK/ERK Activity in Lung Cancer

 

Antoine Karnoub, Ph.D.

Beth Israel Deaconess Medical Center

Role of Stem Cells in the Metastatic Spread of Breast Carcinomas

 
* Alec Kimmelman, M.D., Ph.D.

Dana-Farber Cancer Institute

Defining Biomarkers of Autophagy Addiction in Human Cancers

  

Ivan Maillard, M.D., Ph.D.

University of Michigan

Role of the Ash1L histone methyltransferase in normal and malignant hematopoiesis

 

Michael Major, Ph.D.

University of North Carolina at Chapel Hill

New Functional Components of the KEAP1 Tumor Supressor Protein Complex

Ashby Morrison, Ph.D.

Stanford University

A Novel Mechanism for Tumor Suppression by the Retinoblastoma Protein

 

* Donald Parsons, M.D., Ph.D.

Baylor College of Medicine

Defining molecular subtypes of hepatoblastoma

 

Flavia Pichiorri, Ph.D.

Ohio State University

microRNAs in multiple myeloma diagnosis, prognosis and therapy

Xiaobing Shi, Ph.D.

University of Texas, M.D. Anderson Cancer Center

The roles of PHD fingers in dynamic histone lysine methylation and human cancer

 

Alexander Stegh, Ph.D.

Northwestern University

Development and Characterization of Bc12L12-driven GBM Mouse Models

 

*  Nicola Valeri, M.D.

Ohio State University

MicroRNA-mediated Modulation of genomic stability and apoptosis in sporadic and inflammatory bowel disease associated colon cancer

 

 

* Translational Scholars

 

2009 KIMMEL SCHOLAR AWARDEES

 

*Valerie Brown, M.D., Ph.D.

Children's Hospital of Philadelphia

Preclinical evaluation of targeting the mTOR signaling network in acute lymphoblastic leukemia

 

Paul Chang, Ph.D.

Massachusetts Institute of Technology

New PARP isoforms for cancer therapies

 

Lara Collier, Ph.D.

University of Wisconsin, Madison

Genetic approaches to studying glioma formation and therapy resistance

 

Muller Fabbri, M.D.

Ohio State University Research Foundation

Role of p53 regulation of microRNAs and ultraconserved regions in human cancer

 

Danica Galonic Fujimori, Ph.D.

University of California, San Francisco

Histone-modifying enzymes in cancer: elucidating roles of histone demethylases

 

* Erich Huang, M.D., Ph.D.

Duke University Medical Center

Oncogenic network interrogation for elucidating colon cancer tumorigenesis and identifying novel combination therapies

 
Terry Lechler, Ph.D.

Duke University Medical Center

Mechanism of asymmetric cell divisions and their role in tumor supression

  

* Alexander Minella, M.D.

Northwestern University Feinberg School of Medicine

Deregulated cell cycle controls in the pathogenesis of hematopoietic cancers

 

* Sohail Tavazoie M.D., Ph.D.

Rockefeller University 

Dissecting the mechanisms that regulate the expression of human metastasis suppressor microRNAs

Andrea Ventura, M.D., Ph.D.

Memorial Sloan Kettering Cancer Center

Functional analysis of the miR-17~92 family of oncogenic miRNA clusters

 

Bin Wang, Ph.D.

M.D. Anderson Cancer Center

Functional analysis of new regulatory components in BRCA1 signaling and tumor suppression

 

Zefeng Wang, Ph.D.

University of North Carolina at Chapel Hill

Engineering artificial splicing factors with designed specificities as new cancer treatments

 


 

* Translational Scholars

 

 

2008 KIMMEL SCHOLAR AWARDEES

 

Nabeel Bardeesy, Ph.D.

Massachusetts General Hospital 

Function of the WTX tumor suppressor

 

*Barbara Buttin, M.D.

Northwestern University

The role of synuclein-gamma (SNCG)in the carcinogenesis of uterine papillary serous carcinoma

Richard Gardner, Ph.D.

University of Washington

Understanding the roles of protein deubiquitination in chromatin regulation and other vital nuclear processes

 

* Ramiro Garzon, M.D.

Ohio State University

Epigenetic modulation of DNA methyltransferases by miR-29b: a paradigm for developing novel hypomethylating strategies in AML

 

* Roger Greenberg, M.D., Ph.D.

University of Pennylsvania School of Medicine

Control of homologous recombination at DNA double strand break sites by manipulating lysine-63-linked ubiquitin metabolism

 

Patrick Hu, M.D., Ph.D.

University of MIchigan

Novel regulators of FoxO tumor supressors

 
Tae Hoon Kim, Ph.D.

Yale University

Genome-wide analysis of chrom

  

Karen Liby, Ph.D.

Darthmouth Medical School

New drugs and drug combinations for the prevention and treatment of cancer

 

* Ingo Mellinghoff, M.D.

Memorial Sloan-Kettering Cancer Center

Overcoming PTEN-associated resistance of EGFR kinase

 

Raul Mostoslavsky, M.D., Ph.D.

Massachusetts General Hospital

The role of the SIRT6 chromatin factor in DNA repair and in metabolic homeostasis

 

Cathie Pfleger, Ph.D.

Mount Sinai School of Medicine

Identification and chracterization of mutations in non-tumor cells that promote metastasis

 

Jeroen Roose, Ph.D.

University of California, San Francisco

Increased RasGRP1 function leads to aberrantly sensitized Ras activation and development of T cell lymphomas in humans

 

Lanlan Shen, M.D., Ph.D.

University of Texas, M.D. Anderson Cancer Center

Epiteneticreprogramming in cancer

 

Hengbin Wang, Ph.D.

University of Alabama, Birmingham

Role of Ubp-M and H2A deubiquitination in breast cancer development


* Jen Jen Yeh, M.D.

University of North Carolina at Chapel Hill

Identification and validation of novel targets for the treatment of pancreativ cancer using a prognostic gene signature

 

Hang Yin, Ph.D.

University of Colorado, Boulder

Novel peptide probes to study the activation mechanism of the Epstein-Barr Virus latent membrane protein 1

 

 

* Translational Scholars 

 

 

2007 KIMMEL SCHOLAR AWARDEES

 

 

*Mary Armanios, M.D.

Kimmel Comprehensive Cancer Center at Johns Hopkins

Consequences of telomere shortening on stem cell compartments

 

Jennifer Cochran, Ph.D.

Stanford University

Molecular design and engineering of growth factor receptor antagonists for cancer therapy

 

*Patricia Dahia, M.D., Ph.D.

University of Texas, San Antonio

Energy Metabolism and Cancer

 

Konrad Hochedlinger, Ph.D.

Massachusetts General Hospital

Analysis of the transcription factor Sox2 in spermatogonial stem cells and germ cell cancer

 

Wendong Huang, Ph.D.

Beckman Research Institute of City of Hope

The role of FXR-dependent bile acid signaling in liver regeneration and hepatocarcinogenesis

 

Eric Lai, Ph.D.

Memorial Sloan-Kettering Cancer Center

Functional analysis of microRNA activity in Drosophila cancer models

 

*William Matsui, M.D.

Kimmel Comprehensive Cancer Center at Johns Hopkins

Stem cell regulatory pathways as therapeutic targets in multiple myeloma

 

Kathrin Plath, Ph.D.

University of California, Los Angeles School of Medicine

Function of histone modifications and their enzymes in cancer cells

 

*Sridhar Ramaswamy, M.D.

Massachusetts General Hospital

Creating bioactive feeders for cancer discovery

  

*David Solit, M.D.

Memorial Sloan-Kettering Cancer Center

Predictors of MEK dependence in RAS and BRAF mutant tumors

 

Wenyi Wei, Ph.D.

Beth Israel Deaconess Medical Center

Identification of novel regulatory mechanisms and substrates for Cdh1 and elucidation of its potential tumor suppressor function

 

Jing Yang, Ph.D.

University of California, San Diego

Dissecting the molecular basis of carcinoma metastasis

 

Angela Zarling, Ph.D.

University of Virginia

Targeting of tumor cells utilizing human lymphocytes engineered to express chimeric T-cell receptors specific for phosphorylated MHC-restricted antigens 

 

Rui Zhao, Ph.D.

University of Colorado at Denver

Targeting the Six1 transcriptional complexes for anti-cancer drug design

 

* Translational Scholars

2006 Kimmel Scholar Awardees

Thijn R. Brummelkamp, Ph.D.
Whitehead Institute for Biomedical Research
Functional characterization of the cancer genome

Jan A. Burger, M.D.
The University of Texas M.D. Anderson Cancer Center
Cross talk between the B-cell receptor and CXCR-4 chemokine receptors in chronic lymphocytic leukemia: a new role for ZAP-70

Shridar Ganesan, M.D.
Cancer Institute of New Jersey
Biology of human basal-like breast cancers

Or Gozani, M.D., Ph.D.
Stanford University
ING proteins: linking chromatin modulation to tumor suppression

Amy A. Kiger, Ph.D.
University of California
Roles and regulation of myotubularin-dependent phosphoinositide pathways in cellular differentiation

Andrew L. Kung, M.D., Ph.D.
Dana-Farber Cancer Institute
Tumor hypoxia: mechanisms of adaptation and opportunities for therapeutic targeting

Ming Lei, Ph.D.
University of Michigan
Structural studies of single-stranded telomeric DNA and its binding protein POT1

Loren Michel, M.D.
Washington University in St. Louis
Validating the Trop-2 receptor as a target for anti-cancer therapy

Yanhong Shi, Ph.D.
Beckman Research Institute, City of Hope National Medical Center
The role of nuclear receptor TLX signaling in brain tumors

Kimberly Stegmaier, M.D.
Dana-Farber Cancer Institute
Modulating the ‘undruggable’ oncoprotein with signature-based small molecule library screening

E. Alejandro Sweet-Cordero, M.D.
Stanford University
Functional genomic analysis of oncogenic K-ras signaling

David Traver, Ph.D.
University of California
The role of Runx1 in normal and neoplastic hematopoiesis

Nicola Zanesi, Ph.D.
Ohio State University
Mouse models of the most common human cancers

Xianzheng Zhou, M.D., Ph.D.
The University of Minnesota
Adoptive T-Cell therapy of leukemia by the Sleeping Beauty transposon

Sandra S. Zinkel, M.D., Ph.D. 
Vanderbilt University
The role of proapoptotic BID in mediating apoptosis and the DNA damage response in myeloid homeostasis and leukemogenesis



2005 Kimmel Scholar Awardees

Iannis Aifantis, Ph.D.
University Of Chicago
Mechanisms of Notch-Induced T Cell Leukemia

Rami Aqeilan, Ph.D.
The Ohio State University Research Foundation
The Role of WWOX Tumor Suppressor Gene in Cancer

Catherine Bollard, M.D.
Baylor College of Medicine
Overcoming Tumor Immune Evasion Strategies in Lymphoma

Ruben Carrasco, M.D., Ph.D.
Dana-Farber Cancer Institute
Genetic Models and Translational Studies of Multiple Myeloma

Sandy Chang, M.D., Ph.D.
University of Texas M.D. Anderson Cancer Center
Molecular Mechanisms Controlling the Alternative Lengthening of Telomeres Pathway

Patricia Ernst, Ph.D.
Dartmouth College
MII-Dependent Pathways in Normal and Leukemic Hematopoiesis

Dmitry Fyodorov, Ph.D.
Albert Einstein College ofMedicine
Biochemistry and Genetics of Chromatin Assembly

Lucy Godley, M.D., Ph.D.
University Of Chicago
The Role Of DNMT3B in Mediating The Abnormal DNA Methylation Patterns in Cancer Cells

Johanna Joyce, Ph.D.
Memorial Sloan Kettering Cancer Center
Genetic Analysis of the Cysteine Cathepsin Family of Proteases During Multistage Tumor Development

Chang Kim, Ph.D.
Purdue University
Identification of Trafficking Signals Important for Cancer Cell Interaction ith Regulatory T Cells

Anthony Letai, M.D., Ph.D.
Dana-Farber Cancer Institute
Targeting Apoptotic Defects in Cancer

Gary Luker, M.D.
University Of Michigan
Imaging CXCR4 in Primary and Metastatic Breast Cancer

Toru Nakamura, Ph.D.
University of Illinois at Chicago
Roles of Checkpoint Proteins and Chromatin Modifications in Genome Stability, DNA Repair and Telomere Maintenance

Joel Pomerantz, Ph.D.
The Johns Hopkins University School of Medicine
The Identification of Targets for the Treatment of NF-Kb-DependentCancers

David Watkins, M.D., Ph.D.
The Johns Hopkins University School of Medicine
Basic and Preclinical Investigation of Aberrant Hedgehog Signaling In Cancer

 

2004 Kimmel Scholar Awardees

Ivan Borrello, M.D.
SidneyKimmel Cancer Institute, Johns Hopkins University
Strategies to Enhance Tumor-Specific Immunotherapy in Multiple Myeloma

Scott Briggs, Ph.D.
Purdue University
Functional Characterization of The Multiple Myeloma SET Domain Protein (MMSET)

George Calin, M.D., Ph.D.
Kimmel Cancer Center, Thomas Jefferson University
The Role of Micro RNAs In Human Cancer Development

Diego Castrillon, M.D., Ph.D.
University of Texas, Southwestern Medical Center (Dallas)
Genetic Model Systems and Translational Studies of Endometrial Cancer

James Chen, Ph.D.
Stanford University School of Medicine
Chemical and Genetic Studies of the Hedgehog Pathway

David Ferguson, M.D., Ph.D.
University Of Michigan, Ann Arbor
Genomic Instability in Cancer Mechanisms of Gene Amplification and Roles Of Mre11

Daniel Kamei, Ph.D.
University Of California, Los Angeles
Increasing the Half-Lives of Angiogenesis Inhibitors Using Systems-Level Analyses

Clara Kielkopf, Ph.D.
Johns Hopkins University
Structural Basis Of Normal Pre-Mrna Splice Site Recognition and Its Dysfunction In Neoplasia

Harmet Malik, Ph.D.
Fred Hutchinson Cancer Research Center
Is Genetic Conflict Responsible for Centromere Complexity?

Jeffrey Rathmell, Ph.D.
Duke University Medical Center
Cell Survival and Glucose Uptake in Cancer and Autoimmunity

Jeremy Rich, M.D.
Duke University Medical Center
Transforming Growth Factor Beta Signaling and Targeting In Malignant Gliomas

Brian Schaefer, Ph.D.
Uniformed Services University of The Health Sciences
Role Of NF-Kb Signaling Intermediates In The Etiology Of MALT Lymphoma

Sheila Stewart, Ph.D.
Washington University
Molecular Mechanisms of Cellular Immortality

Kwok-Kin Wong, M.D., Ph.D.
Dana Farber Cancer Institute
The Genetic Role of Telomere Dynamics and DNA Damage Response in Cancer And Aging

Yihua Yu, Ph.D.
University Of Utah
An Integrated Docking/Imaging Device for Cancer Radioimmunotherapy

2003 Kimmel Scholar Awardees

Joanne Chan, Ph.D.
Children's Hospital, Boston
Genetic dissection of angiogenesis in the zebrafish

Nancy DeMore, M.D.
University of North Carolina at Chapel Hill
Molecular mechanisms controlling human tumor dormancy

Nicholas Gaiano, Ph.D.
Johns Hopkins University
The regulation of neural stem cell proliferation by notch and FGF signaling

David Jeruzalmi, Ph.D.
Harvard University
Structure and function of the mini-chromosome maintenance (MCM) assembly

Ann L. Kirchmaier, Ph.D.
Purdue University
Epigenetic regulation of Epstein-Barr viralgene expression

Motonari Kondo, M.D., Ph.D.
Duke University
Lineage infidelity: relationship between plasticity of lymphoid progenitors and leukemogenesis

Sang Eun Lee, Ph.D.
University of Texas, San Antonio
Role of chromatin remodeler in repair of damaged DNA

Mark Levis, M.D., Ph.D.
Johns Hopkins University
Targeting FLT3 as a novel, specific therapy for leukemia

Linda Liau, M.D., Ph.D.
University of California, Los Angeles
Characterization of GDOX, a novel putative oncogene preferentially expressed in human glioma

Ari Melnick, M.D.
Albert Einstein College of Medicine
Development of structure-guided molecular targeted transcription therapy for b-cell lymphoma

Akhilesh Pandey, M.D., Ph.D.
Johns Hopkins University School of Medicine
Molecular dissection of EGF receptor signal transduction

Roberto Pili, M.D.
Johns Hopkins University
Novel combination therapy targeting tumor angiogenesis with chromatin remodeling agents

Norman Sharpless, M.D.
University of North Carolina at Chapel Hill
The regulation of the tumor suppressor p16INK4a in cancer and aging

Said Sif, Ph.D.
Ohio State University
Role of histone methyltransferase-containing human SWI/SNF complexes in cancer

Srinivasa Srinivasula, Ph.D.
Thomas Jefferson University
Characterization of caspase linker domain(s)

Robert Wechsler-Reya, Ph.D.
Duke University
The molecular basis of childhood brain tumors